Monday, April 20, 2015

Hormonal Treatment of Micropenis in Childhood with Testosterone or HCG

In today's post we will see the results of a relatively new study (2013), published in the Indian Journal of Urology. The name of the study is "Penile growth in response to hormone treatment in children with micropenis" and as you have probably guessed, the purpose of the study was to determine the safety and efficacy of hormonal therapy (Testosterone or Human Chorionic Gonadotropin) in treating children with a very small penis.

As a side note, this is the second study of this kind (see first link at the bottom) we examine in our website, with both of them having similar and very encouraging results.

Patient Profile & Methods
A total of 25 children (age <18 years) who met the criteria for the micropenis condition participated in the study. Boys more than 11 years old were treated using a standard protocol of 1,500 to 2,000 IU human chorionic gonadotrophin (HCG) administrated intramuscularly, once per week, for 6 weeks.

Boys younger than 11 years old were treated with parenteral testosterone enanthate, 25 mg once a month for 3 consecutive months.

The mean age was 9.24 ± 3.95 years, with the patient's age ranging from 3 to 14 years old.

Children with cryptorchidism, absence of testicles, hypospadias and other genital anomalies were excluded from the study. Penis length (flaccid and stretched) and testicular volume were measured before and after hormonal treatment in all participants.

Penis length (flaccid and stretched) and testicular volume measurements were taken before and after the treatment in all children, by the same physician, using a wooden spatula. The spatula was pressed against the pubic bone, depressing the suprapubic fat as close as possible to ensure that the "burried" part was also included. Measurement was made along the dorsum of the penis to the tip of the glans.

Results
Response to the treatment was evaluated in terms of size of the penis and changes in testosterone levels.

In the less than 11 years group, mean penile length increased significantly after hormonal treatment from an average 1.554 cm to 3.18 cm. In the older group, the mean penile length also increased significantly from 2.642 cm to 6.428 mm. As you can see, the average penis length increased more than double in both groups!




In both groups, testicular volume and the testosterone levels also increased.

Importantly, no significant adverse events related to the hormonal treatment were reported.

Conclusions
It's obvious that treatment of micropenis in childhood with hormones is feasible and the results are very good and promising! Here's what the authors had to say:

"Management of isolated micropenis revolves around testosterone (direct administration or encouraging the patient's body to make its own), and results with respect to increase in penile length are promising."


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References
Nerli RB, Guntaka AK, Patne PB, Hiremath MB. Penile growth in response to hormone treatment in children with micropenis. Indian J Urol 2013;29:288-91

3 comments :

  1. I wish I had been given this treatment when I was younger.
    It possibly would have drastically changed my self confidence and body image.
    Technically I am not a micro-penis, but my 1/10th of an inch is not any comfort.

    ReplyDelete
  2. Does anyone know of a private specialist in London where I can take my 7 year old son for assessment. I can't imagine the NHS wanting to fund this. I'd pay anything to get treatment for him so that he can have a normal life

    ReplyDelete
    Replies
    1. Hi, I'm wondering if you ever found a private consultant in London which treated your son?

      Delete

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